Decapeptide-52

Good

Peptide

Decapeptide-52 at a glance

  • Also called peptide 14 or OS-01
  • Developed by the brand OneSkin
  • Claims say it interrupts cellular senescence
  • More independent research needed

Decapeptide-52 description

Decapeptide-52, also called peptide 14 and referred to by cosmetic brand OneSkin as “OS-01”, is an exclusive peptide used extensively in the company’s products. OneSkin claims this peptide interrupts the process of cellular senescence. This process occurs when cells that have stopped proliferating (sometimes referred to as “zombie cells”) send out pro-aging factors to surrounding cells, creating a waterfall effect that leads to visible signs of aging. In essence, the ongoing presence of senescent cells gets the good cells to do bad things that impact skin’s health and appearance. Limited research at this time indicates decapeptide-52 might indeed be able to interrupt the process of cellular senescence, though it must be noted that most studies have been conducted by either OneSkin (which developed this peptide) or people associated with the brand. While we’re cautiously optimistic about the potential of this ingredient, more independent studies must be conducted before determining if it’s a must-add to your skin care routine.

Decapeptide-52 references

  • OneSkin.com, Website, Accessed October 2024
  • NPJ Aging, May 2023, ePublication

Peer-reviewed, substantiated scientific research is used to assess ingredients in this dictionary. Regulations regarding constraints, permitted concentration levels and availability vary by country and region.

Ingredient ratings

Best

Proven and supported by independent studies. Outstanding active ingredient for most skin types or concerns.

Good

Necessary to improve a formula's texture, stability, or penetration.

Average

Generally non-irritating but may have aesthetic, stability, or other issues that limit its usefulness.

Bad

There is a likelihood of irritation. Risk increases when combined with other problematic ingredients.

Worst

May cause irritation, inflammation, dryness, etc. May offer benefit in some capability but overall, proven to do more harm than good.

unknown

We couldn't find this in our ingredient dictionary. We log all missing ingredients and make continuous updates.

Not rated

We have not yet rated this ingredient because we have not had a chance to review the research on it.